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Alicia Kaestli

I'm a serial co-founder building AI products in life sciences and healthcare.

Currently I'm the Co-Founder and Senior Director of Applied AI & Product at Flagship Labs 109, a deep-tech company applying cutting-edge physics, robotics, and computer vision to transform how biology is visualized. At Flagship Pioneering, I've worked on company creation including co-founding and leading computational efforts at Abiologics and Metaphore Biotechnologies, both generative AI startups focused on peptide and antibody design. My earlier experience includes leading machine learning initiatives at Amgen, deploying AI across the drug discovery, development, and commercialization pipeline, and co-leading venture investments and partnerships with Amgen Ventures and the Novartis Strategic VC Fund.

If you're passionate about new science and technology, please connect!

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Writing

AI has completely changed how I work on life sciences and healthcare problems. I started a blog to track what's emerging and share where I think this is all going. More on Substack. (Views my own.)

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Companies

I'm passionate about building companies at the intersection of breakthrough science and computation. Here are some of the ventures I've helped build at Flagship Pioneering:

FL109
Flagship Labs 109, Inc. in stealth

Flagship Labs 109, Inc. (FL109) is an early-stage deep tech company pioneering the use of artificial intelligence, physics and hardware to transform the way we see biology.

I co-founded Flagship Labs 109 from the beginning. Join us!

Abiologics, Inc.
Company website

Abiologics, Inc. is on a mission to make biology better through chemistry. We are pioneering the development of a transformational new class of medicines that is unlocked by novel synthetic and computational technologies.

I built the early computation team and strategy, and, after the team was up and off the ground, pivoted to managing company operations. I'm part of the company's founding team.

Metaphore Biotechnologies
Company website

Metaphore Biotechnologies is harnessing the power of biomimicry and machine learning to unlock the transformative therapeutic potential of functional molecular mimics. The company's MIMiC™ platform is a computationally driven bioplatform designing new therapeutics where function, specificity, and selectivity can be optimized. Metaphore is focused on making previously intractable drug targets accessible and unlocking breakthroughs that outperform today's drugs for maximum patient impact.

I built the early digital intrastructure team, and helped lead strategy and operations.