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Alicia Kaestli

I build biotech and deep tech companies at the convergence of ML, physics, and biology at Flagship Pioneering in Cambridge, MA.

At Flagship Pioneering I've worked on founding the early vision, team, and strategy at Metaphore, Abiologics, and am now building Flagship Labs 109. Previously, I was an ML project lead at Amgen working on buiding and deploying AI across the drug discovery, development, and commercialization pipeline. I had the opportunity to co-lead investments and partnerships as part of Amgen Ventures, lead the data science diligence on the team that championed a landmark UK Biobank proteomics study, and develop ML-risk prediction models using an incredible deep phenotyping dataset (i.e., genomics, 3D imaging) at deCODE genetics.

I love meeting builders passionate about new science and technology. Please set up time on calendry to chat!

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Writing

I explore the frontiers where computer vision, generative AI, and robotics meet biotech and medicine. My blog is where I share insights, ask interesting questions, and occasionally geek out about emerging technologies. Join the conversation on Substack! (Views are my own, not my employer's.)

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Companies

I'm passionate about building companies at the intersection of breakthrough science and computation. Here are some of the ventures I've helped build at Flagship Pioneering:

FL109
Flagship Labs 109, Inc. in stealth

Flagship Labs 109, Inc. (FL109) is an early-stage deep tech company pioneering the use of artificial intelligence, physics and hardware to transform the way we see biology.

I co-founded Flagship Labs 109 from the beginning. Join us!

Abiologics, Inc.
Company website

Abiologics, Inc. is on a mission to make biology better through chemistry. We are pioneering the development of a transformational new class of medicines that is unlocked by novel synthetic and computational technologies.

I built the early computation team and strategy, and, after the team was up and off the ground, pivoted to managing company operations. I'm part of the company's founding team.

Metaphore Biotechnologies
Company website

Metaphore Biotechnologies is harnessing the power of biomimicry and machine learning to unlock the transformative therapeutic potential of functional molecular mimics. The company's MIMiC™ platform is a computationally driven bioplatform designing new therapeutics where function, specificity, and selectivity can be optimized. Metaphore is focused on making previously intractable drug targets accessible and unlocking breakthroughs that outperform today's drugs for maximum patient impact.

I built the early digital intrastructure team, and helped lead strategy and operations.